抗生素及益生菌序贯给药对肠易激综合征患者下消化道症状及排便的改善情况研究

Research on sequential administration of antibiotics and probiotics in improving lower digestive tract symptoms and defecation of irritable bowel syndrome patients

目的研究抗生素及益生菌序贯给药对肠易激综合征患者下消化道症状及排便的改善作用。方法选取2010年8月至2013年8月肠易激综合征患者100例,抽签随机分为观察组与对照组,每组50例。观察组给予抗生素及益生菌序贯给药,对照组给予益生菌制剂,比较两组患者的治疗有效率、下消化道症状及排便的改善效果。结果观察组治疗总有效率为98%,与对照组的84%比较显著提高(P<0.05);观察组治疗后4、8、12周时下消化道症状总评分与对照组比较显著降低(P<0.05);观察组治疗后排便异常发生率为8%,与对照组的24%比较显著减少(P<0.05)。结论抗生素及益生菌序贯给药能提高肠易激综合征患者的治疗有效率,有效改善患者下消化道症状及排便情况,有临床应用推广价值。

Objective To research the sequential administration of antibiotics and probiotics in improving lower digestive tract symptoms and defecation of irritable bowel syndrome patients. Methods One hundred irritable bowel syndrome patients during August 2010 and August 2013 were randomly divided into observation group and contrast group with 50 cases in each group. Patients in the observation group were given sequential administration of antibiotics and probiotics,while patients in the contrast group were given administration of probiotics. Compared the total effective rate,lower digestive tract symptoms and defecation improvement conditions. Results The total effective rate in the observation group was 98%,which was obviously higher than that in the contrast group（ P〈0. 05）. In the observation group,the general scores of lower digestive tract symptoms of 4,8,12 weeks after treatment were all significantly lower than those in the contrast group（ P〈0. 05）. After treatment,the defecation abnormal occurrence rate in the observation group was 8%,which was obviously lower than that in the contrast group（ P〈0. 05）.Conclusion Sequential administration of antibiotics and probiotics is proved to be effective in improving the total effective rate of irritable bowel syndrome patients. It can effectively improve the lower digestive tract symptoms and defecation conditions. Thus,it deserves to be widely promoted in the clinical field.