中国人群CDH23基因多态性与噪声性听力损失易感性关系研究的meta分析

Association between CDH23 gene polymorphisms and susceptibility to noise-induced hearing loss in the Chinese population： a meta-analysis

目的对中国人群钙黏素23（CDH23）基因多态性与噪声性听力损失（NIHL）易感性关系进行meta分析。方法于2016年6月，检索CNKI、维普、万方、PubMed数据库获取关于中国人群CDH23基因多态性与NIHL易感性关系的研究，按纳入与排除标准筛选文献、提取资料，采用RevMan5．3进行meta分析。结果共纳入3篇中文文献。meta分析结果显示，CDH23-rs1227049位点C等位基因NIHL发病风险是G等位基因的0．82倍（95％CI：0．39—1．73），显性模型CG＋CC基因型NIHL发病风险是GG基因型的0．70倍（95％CI：0．34～1．43），隐性模型CC基因型NIHL发病风险是CG＋GG基因型的1．23倍（95％Ch0．28—5．43），加性模型CC基因型NIHL发病风险是GG基因型的1．05倍（95％CI：0．20～5．44），但差异均无统计学意义（均P〉0．05）；CDH23-rs1227051位点T等位基因NIHL发病风险是C等位基因的0．98倍（95％CI：0．71～1．37），显性模型CT＋CC基因型NIHL发病风险是TT基因型的1．09倍（95％CI：0．75～1．57），但差异也均无统计学意义（均P〉0．05）。结论尚不能认为CDH23-rs1227049、CDH23-rs1227051是NIHL的易感基因位点。

Objective To investigate the association between cadherin-23（CDH23） gene polymorphisms and susceptibility to noise-induced hearing loss （NIHL） in the Chinese population through a meta-analysis. Methods In June 2016, CNKI, VIP, Wanfang Data, and PubMed were searched for studies on the association between CDH23 gene polymorphisms and susceptibility to NIHL in the Chinese population. The articles were screened according to inclusion and exclusion criteria and related data were extracted. RevMan 5.3 was used for the meta-analysis. Results A total of three Chinese articles were included. For CDH23-rs1227049, the risk of NIHL in people with C allele was 0.82 times （95%CI 0.39-1.73） that in people with G allele, the risk of NIHL in people with CG＋CC genotype in the dominant model was 0.70 times （95%CI 0.34-1.43） that in people with GG genotype, the risk of NIHL in people with CC genotype in the recessive model was 1.23 times （95%CI 0.28-5.43 ） that in people with CG＋GG genotype, and the risk of NIHL in people with CC genotype in the additive model was 1.05 times （95%CI 0.20-5.44） that in people with GG genotype （all P〉0.05）. For CDH23-rs1227051, the risk of NIHL in people with T allele was 0.98 times （95%CI 0.71-1.37） that in people with C allele, and the risk of NIHL in people with CT＋CC genotype in the dominant model was 1.09 times （95%CI 0.75-1.57） that in patients with TT genotype （both P〉0.05）. Conclusion There is still no enough evidence for the determination of CDH23- rs1227049 and CDH23-rs 1227051 to be the susceptibility gene loci of NIHL.