复发性急性胰腺炎危险因素分析

Analysis of Risk Factors of Recurrent Acute Pancreatitis

背景：复发性急性胰腺炎（RAP）是急性胰腺炎的一种特殊类型,明确病因是避免RAP复发的关键。目的：探讨RAP相关的危险因素。方法：回顾性分析43例RAP患者和130例单次发作的急性胰腺炎患者（对照组）的临床资料,包括病因构成、病情严重度、实验室检查和影像学结果,分析RAP反复发作的危险因素。结果：单因素分析显示,RAP组和对照组病因构成、病情严重度、血清胆固醇、钙离子、白细胞计数、淀粉酶、ALT、AST、总胆红素、直接胆红素、C反应蛋白水平相比差异均无统计学意义（P〉0.05）,而三酰甘油、血糖和CT评分均显著高于对照组（t=3.260,P〈0.05;t=2.720,P〈0.05;t=2.162,P〈0.05）。Logistic回归分析结果表明三酰甘油、血糖和CT评分为RAP的危险因素（OR=1.86,95%CI：1.05-3.68,P=0.03;OR=1.23,95%CI：1.01-1.50,P=0.04;OR=2.46,95%CI：1.00-6.03,P=0.04）。结论：血清三酰甘油、血糖和CT评分与RAP的反复发作密切相关。

Background： Recurrent acute pancreatitis（RAP） is a special type of acute pancreatitis（AP）.Finding the cause is the key to avoid the recurrence of RAP.Aims： To investigate the risk factors of RAP.Methods： The clinical data of 43 patients with RAP and 130 patients with only one time AP（control group） were retrospectively analyzed.Risk factors of recurrence of RAP were analyzed.Results： Univariate analysis showed that no significant differences in etiology,severity,serum levels of cholesterol,calcium,white blood cell count,amylase,ALT,AST,total bilirubin,direct bilirubin and Creactive protein were found between RAP group and control group（P〉0.05）.Serum triglyceride level,blood glucose level and CT score in RAP group were significantly higher than those in control group（t = 3.260,P〈0.05;t = 2.720,P〈0.05;t = 2.162,P〈0.05）.Logistic regression analysis demonstrated that serum triglyceride level,blood glucose level and CT score were risk factors of RAP（OR = 1.86,95% CI： 1.05-3.68,P = 0.03;OR = 1.23,95% CI： 1.01-1.50,P = 0.04;OR = 2.46,95% CI： 1.00-6.03,P = 0.04）.Conclusions： The recurrence of RAP is related with serum triglyceride level,blood glucose level and CT score.