MicroRNA在炎症性肠病中的调控机制和临床应用

Regulatory Mechanism and Clinical Application of MicroRNAs in Inflammatory Bowel Disease

炎症性肠病(IBD)是一类慢性非特异性肠道炎性疾病,发病机制尚未明确。MicroRNA(miRNA)是一类内源性非编码RNA,在转录后水平调节目的基因表达。研究发现,miRNA参与对肠黏膜屏障和黏膜免疫系统的调控,miRNA表达异常与IBD的发生相关。本文就miRNA在IBD中的调控机制和临床应用作一综述。

Inflammatory bowel disease（IBD） is a chronic nonspecific intestinal inflammatory disease and its etiology is not yet clarified.MicroRNAs（miRNAs） is a class of endogenous noncoding RNA that exerts post-transcriptional regulation on gene expression.Studies found that miRNAs is involved in the regulation of intestinal mucosal barrier and mucosal immune system;abnormal expression of miRNAs is associated with the occurrence of IBD.This article reviewed the regulatory mechanism and clinical application of miRNAs in IBD.