摘要
微流控分析系统与宏观条件下的分析体系相比,具有样品和试剂消耗小、传质传热效率高、生物相容性较好、高通量并行分析、功能单元集成化、微型化及自动化控制等特点,在分析化学尤其是生命分析化学领域得到了广泛应用。本文以涉及细胞的微流控技术为切入点,主要介绍了近五年来微流控芯片相关技术的发展,如芯片材料与制作技术、表面改性技术和液滴技术等,并简单总结微流控技术在药物筛选和细胞分析等生命分析化学领域的研究应用进展。
In comparison with with macro analysis system, microfluidic analysis system has many advantages such as small sample and reagent consumption, mass and heat transfer efficiently, good biocompatibility, high-throughput parallel analysis, functional unit integration, miniaturization, and automation control and so on. It has been applied in the analytical chemical, especially in life analytical chemistry. In this review, we mainly focused on the progress of cell analysis related microfluidic technologies during the past five years, such as material and fabrication, surface modification and droplet techniques. Then we briefly summarized the applications of microfluidic techniques on drug screening and cell analysis.
作者
张逢
高丹
梁琼麟
ZHANG Feng GAO Dan LIANG Qiong-Lin(Division of Life Science and Health, The Graduate School at Shenzhen, Tsinghua University, Shenzhen 518055, China Department of Chemistry, Tsinghua University, Beijing 100084, China)
出处
《分析化学》
SCIE
EI
CAS
CSCD
北大核心
2016年第12期1942-1949,共8页
Chinese Journal of Analytical Chemistry
基金
国家自然科学基金(Nos.21305074
21175080
U1333132)
国家科技重大专项(Nos.2013ZX09507005
2014ZX09304307001)资助~~
关键词
微流控技术
药物筛选
细胞分析
综述
Microfluidic technology
Drug screening
Cell analysis
Review
