急性心力衰竭患者联合检测血清糖类抗原CA125和N末端脑钠肽原的临床意义

Prognostic value of carbohydrate antigen-125 and N-terminal probrain natriuretic peptide levels in patients with acute heart failure

目的对联合检测血清糖类抗原CA125(CA125)和N末端脑钠肽原(NT-proBNP)水平用于预测急性心力衰竭患者预后的价值进行评估。方法纳入68例急性左心衰竭发作24 h之内入院的患者,检测血清NT-proBNP和CA125水平,根据患者出院6个月时的预后,分为死亡(6个月之内死亡)、再发作(存活,有急性左心衰竭再发作)和稳定(存活且无心力衰竭再发作)组,对单独和联合应用NT-proBNP和CA125水平用于预测患者预后的价值进行分析。结果不同分组患者的CA125水平差异有统计学意义(P=0.013),再发作组和死亡组患者的血清CA125水平高于稳定组,差异有统计学意义(P=0.004和0.030),CA125和NT-proBNP均为阳性者的死亡风险高于其他患者。结论联合检测血清CA125和NT-proBNP水平,可以准确预测急性心力衰竭患者出院6个月之内的死亡风险。

Objective To evaluate the prognostic value of serum carbohydrate antigen-125 （CA125） and N-terminal pro-brain natriuretic peptide （NT-proBNP） levels in patients with acute heart failure. Methods Sixty-eight patients with acute left heart failure were included and divided into three groups according to different prognosis six months after discharge： dead （dead during 6 months）, recurred （alive with recurred acute left heart failure） and stable （alive without recurred acute left heart failure） groups. The prognostic value of serum NT-proBNP and CA125 levels alone and in combination were analysed. Results The serum CA125 levels were significantly different between different groups （P = 0.013）, and the levels were significantly increased in recurred and dead groups compared with stable group （P = 0.004 and 0.030, respectively）. The mortality risk during 6 months after discharge was significantly higher in patients with positive CA125 and NT-proBNP compared with other patients. Conclusions The combination of CA125 and NT-proBNP levels could accurately predict the mortality risk in patients with acute heart failure during six months after discharge.