超声热效应下海藻酸钠微球力学特性模型分析

Numerical model of shear module of alginate micro-beads under ultrasonic thermal effect

目的对超声刺激产生的热效应下海藻酸钠微球机械特性变化进行模型分析。方法采用压缩实验,对微球压缩率、压应力进行记录,通过赫兹模型测量其剪切模量。在不同的超声刺激条件下,如改变超声刺激时间、超声刺激强度和超声刺激脉冲比率,检测超声刺激后微球水溶液温度和微球剪切模量的变化。对微球在不同温度下,剪切模量的变化进行模型化分析。通过实验再次验证模型对于预测微球剪切模量的高度可行性。结果超声刺激引起被刺激水溶液温度升高以及海藻酸钠微球剪切模量的升高;通过模型分析,获得海藻酸钠微球剪切模量和超声刺激后与水溶液温度相关性,以及二者的关系函数。结论海藻酸钠微球剪切模量和水溶液温度的关系函数可作为不同温度下微球剪切模量的预测模型,为海藻酸钠微球在具有温度变化环境中的应用提供良好的基础研究支持。

Objective To establish a numerical model of the shear module of alginate beads stimulated by ultrasonic sound. Methods The compression ratio and force of alginate beads were recorded with the compression test. The shear module of beads was measured with a Hertz model. When to alginate beads were stimulated ultrasonically for different durations, the ultrasonic stimulation power, ultrasonic pulse ratio, and changes in the shear module and solution temperature were measured. Results Temperatures in the solution and shear module of alginate beads increased under different ultrasonic stimulation conditions. Modeling analysis revealed the relationship between the shear module of alginate beads and the corresponding temperature. The shear module of beads was in a quadratic equation with temperature（20℃ 〈 T 〈 80℃ ）. Residual analysis showed that the function had a good predictive and descriptive effect. Conculsion This function can be used as a good predictive model of the shear module of alginate beads at different temperatures. The results can facilitate the application of alginate beads to medical and biological research.