时钟基因的研究进展及临床应用

Research progress and clinical application of clock genes

哺乳类动物中普遍存在一种随着昼夜更替,生理和行为呈周期性变化的现象,这种现象的核心机制来源于时钟基因的转录、翻译形成的反馈回路。近年来,生物节律的紊乱与肿瘤发生的关系已经成为研究的热点,迄今许多研究指出生物节律紊乱与各类疾病,包括癌症的发生发展存在着相关关系。一类基于生物节律的治疗模式,在提高癌症患者的药物耐受剂量、降低毒副反应上的作用已经得到了认可。本文将对时钟基因研究的进展及时钟基因与癌症治疗的关系做一综述。

As a consequence of day and night replacement,the physiology and behavior of mammal presented a periodic change,and the core mechanism of it comes from the transcription/translation feedback loops of a group of core clock genes. Currently,a relationship between the dysregulation of clock rhythm and cancer has become a research hotspot. Previous studyies have revealed that the dysregulation of clock rhythm leads to or affects a variety of diseases,including tumors. A new therapeutic mode based on biological rhythm has been gotten the approval in improving treatment tolerability,reducing toxic side effects. In this review,we briefly summarize the advance of circadian clock genes and chemotherapy for tumor.