疏风解毒胶囊佐治慢性阻塞性肺疾病急性加重期伴肺部感染的临床观察

Clinical observation of Shufeng Jiedu Capsule in the treatment of acute exacerbation of chronic obstructive pulmonary disease with pulmonary infection

目的:观察疏风解毒胶囊在治疗慢性阻塞性肺疾病急性加重期(AECOPD)伴肺部感染的临床治疗效果。方法:将本院收治的100例伴肺部感染AECOPD患者按照入院时间随机纳入对照组与治疗组,各50例。对照组予头孢曲松抗感染治疗,治疗组同时予以疏风解毒胶囊治疗。两组患者同时按AECOPD处理治疗。观察两组患者治疗期间咳嗽、咳痰、肺部啰音变化变化情况,以及治疗前、治疗第3、10天超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、肺部感染评分(CPIS)变化情况,对临床治疗效果进行评价分析。结果:治疗组患者咳嗽、咳痰、肺部啰音平均消失时间小于对照组(P<0.05)。治疗3d、10d后,治疗组hs-CRP、PCT、CPIS指标低于对照组(P<0.05),其中,治疗组hs-CRP、PCT基本恢复正常参考值水平;治疗组患者有效率大于对照组(P<0.05)。结论:联合疏风解毒胶囊治疗能够加快伴肺部感染的AECOPD患者肺部感染控制,促进患者恢复。

Objective：To observe clinical curative effective of Shufeng Jiedu Capsule in the treatment of acute exacerbation of chronic obstructive pulmonary disease（AECOPD） with pulmonary infection.Methods：One hundred patients with AECOPD with pulmonary infection were divided into control group and treatment group,50 cases in each group.The control group was given ceftriaxone,the treatment group was given Shufeng Jiedu Capsule besides of the Ceftriaxone.The course of treatment was 10 days.The clinical symptoms and signs（cough,sputum,pulmonary rales）,content changes of hypersensitive c-reactive protein（hs-CRP） and calcitonin（PCT） in blood and pulmonary infection score（CPIS） were observed after the treatment for 3 days or 10 days.Results：The cardinal symptoms and signs of recovery time of treatment group were less than those of control group（P〈0.05）,and the hs-CRP and PTC and CPIS were less than control group after the treatment for 3 days and 10 days（P0.05）.The totle effective rate of the treatment group were better than that of the control group（P0.05）.Conclusion：Shufeng Jiedu Capsule could relieve AECOPD with pulmonary infection,and promote clinical recovery.