脂化前列腺素E_1联合α-硫辛酸治疗糖尿病下肢血管病变对炎性因子及氧化应激的影响

Effects of Treating Diabetes Lower Extremity Venous Disease with Lipo-prostaglandin E_1 Combined with α-lipoic Acid on Inflammatory Factors and Oxidative Stress

目的探讨脂化前列腺素E1联合α-硫辛酸治疗糖尿病下肢血管病变对炎性因子及氧化应激的影响。方法选取82例糖尿病下肢血管病变患者随机分为实验组和对照组,各41例,实验组给予脂化前列腺素E1联合α-硫辛酸治疗,对照组给予脂化前列腺素E1治疗,两组疗程均为3周;观察两组患者治疗前后细胞因子的变化,并评价两组患者临床疗效。结果两组患者治疗后hs-CRP、IL-6、TNF-α均较治疗前显著降低(P<0.01),实验组各指标均显著低于对照组(P<0.01);两组患者治疗后SOD、8-OHd G均组治疗前明显降低(P<0.05),实验组各指标均明显低于对照组(P<0.05);实验组总有效率为92.68%,明显优于对照组的75.61%(P<0.05)。结论脂化前列腺素E1联合α-硫辛酸治疗糖尿病下肢血管病变患者,有助于减轻炎症反应及氧化应激状态,从而提高临床疗效,是一种有效的联合用药方案。

Objective To explore the effects of treating diabetes lower extremity venous disease with lipo-prostaglandin E, combined with α-lipoic acid on inflammatory factors and oxidative stress. Methods 82 patients with diabetes lower extremity venous disease were divided into experimental group and control group with 41 patients in each group. Patients in experimental group were treated with lipo-prostaglandin E1 combined with α-lipoic acid and those in control group were treated with lipo-prostaglandin E1. The course of treatment of two groups were three weeks. The changes of cytokines of patients in two groups before and after the treatment were observed and their curative effects were appraised. Results Hs-CRP, IL-6 and TNF-α of patients in two groups decreased significantly （P〈0.01） and indexes in experimental group were significantly lower than those in control group （P〈0.01）. SOD and 8-OHdG of patients in two groups were significantly lower than those of patients before the treatment （P〈0.05） Indexes of experimental group were significantly lower than those of control group（P〈0.05） Total effective rate of experimental group was 92.6%, which was significantly higher than that of control group of 75.61%（P〈0.05）. Conclusion Treating diabetes lower extremity venous disease with lipo-prostaglandin E1 combined with α-lipoic acid is an effective drug combination regimen, which is conductive to relieving inflammatory reaction and oxidative stress state so as to improve clinical curative effects.