新型喹诺酮类衍生物的合成

Synthesis of Novel Quinolone Derivatives

以4-硝基愈创木酚、乙氧甲叉基丙二酸二乙酯、2-巯基苯并噻唑等为原料,经烃化、还原、缩合、环合、水解、缩合酰化等反应合成了2个喹诺酮-3-甲酰胺类衍生物、2个喹诺酮-3-甲酸硫酯类衍生物,化合物结构经核磁氢谱、质谱确证,结构未见文献报道,为新型喹诺酮类小分子药物的研究提供了化合物基础。

Two novel quinolone-3-carboxamides and two novel quinoline-3-carbothioates were synthesized form 2-methoxy-4-nitrophenol,ethoxy methylene diethyl malonate and 2-mercapto benzothiazole via alkylation,reduction,condensation,cyclization,hydrolyzation and acylation etc.The structures were confirmed by1 HNMR and MS.This work provides a compound foundation on the development of novel quinolones drug.