摘要
Large scaled uniform and size-controllable magnetic submicroparticles(MSPs) were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe^(3+) and Na Ac contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy(SEM), X-ray power diffraction(XRD) and vibrating sample magnetometer(VSM). The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe^(3+) and NaA c. In addition, the hemolysis and cytotoxicity of Fe_3O_4 MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT(3-(4,5-dimethylthuazol-2-yl)-2,5-diphenyltetrazolium bromide) assay, the interactions between MSPs and adhesive mouse fibroblast cell line(L929) were probed. Larger size of Fe_3O_4 MSPs demonstrates lower cell viability following an exposure to the cells.
Large scaled uniform and size-controllable magnetic submicroparticles（MSPs） were synthesized via solvothermal method with ferric chloride as iron source and sodium acetate as trapping agent. The influence of Fe^3＋ and Na Ac contents on the size distribution of MSPs was investigated. The structural and morphological properties of the synthesized particles were studied by scanning electron microscopy（SEM）, X-ray power diffraction（XRD） and vibrating sample magnetometer（VSM）. The well-dispersed MSPs with size of 100-1000 nm were obtained by simply adjusting the contents of Fe^3＋ and NaA c. In addition, the hemolysis and cytotoxicity of Fe3O4 MSPs, and their ability to case arrest in cell life-cycles were studied. The results indicate that larger size could lead to lower hemolysis. From MTT（3-（4,5-dimethylthuazol-2-yl）-2,5-diphenyltetrazolium bromide） assay, the interactions between MSPs and adhesive mouse fibroblast cell line（L929） were probed. Larger size of Fe3O4 MSPs demonstrates lower cell viability following an exposure to the cells.
基金
Project(2013DFA5129)supported by the International Science and Technology Cooperation Program of China
