摘要
目的:研究葡甲胺对瑞格列奈的助溶机理。方法:选用助溶剂葡甲胺与瑞格列奈生成分子络合物,以增加药物溶解度,并采用差示扫描量热(DSC)法进行判断。采用HPLC-MS分析葡甲胺-瑞格列奈分子络合物的组成,并采用HPLC法考察葡甲胺与瑞格列奈不同摩尔比、葡甲胺不同浓度及不同温度对分子络合物稳定性的影响。结果:葡甲胺与瑞格列奈形成了分子络合物,瑞格列奈与葡甲胺的最佳摩尔比为1∶1。随着葡甲胺浓度增加,瑞格列奈的溶解度也随之增加。温度升高,分子络合物的稳定性降低。结论:葡甲胺对其有良好的助溶作用。
Objective： To study the solubility of repaglinide in meglumine aqueous solution. Methods： In order to increase the solubility of repaglinide, meglumine was used to react with repaglinide and obtain a molecular complex. The structure and composition of meglumine-repaglinide complex was analyzed by DSC, HPLC and HPLC-MS. Results： Meglumine and repaglinide formed a molecu- lar complex, and their best molar ratio was 1 ： 1. With the concentration increase of meglumine, the solubility of repaglinide also in- creased. The stability of molecular complexes decreased with the temperature increase. Conclusion： Meglumine plays a good role in the solubilization of repaglinide.
出处
《中国药师》
CAS
2017年第1期189-192,共4页
China Pharmacist
关键词
葡甲胺
瑞格列奈
分子络合物
助溶
Meglumine
Repaglinide
Molecular complex
Solubilization
