弥漫大B细胞淋巴瘤患者血清超氧化物歧化酶水平变化及意义

Change and significance of serum superoxide dismutase level in patients with diffuse large B-cell lymphoma

目的探讨弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)患者血清超氧化物歧化酶(superoxide dismutase,SOD)水平变化及临床意义。方法 DLBCL患者57例为观察组,同期淋巴结反应性增生患者40例为对照组,检测2组血清SOD水平并比较;分析DLBCL患者血清SOD水平与临床病理参数及化疗效果的关系。结果观察组血清SOD水平[(149.11±27.17)u/mL]明显低于对照组[(160.13±22.98)u/mL](P<0.05);不同年龄、性别DLBCL患者血清SOD水平比较差异无统计学意义(P>0.05),不同国际标准化预后指数(international prognostic index,IPI)评分、临床分期患者SOD水平比较差异有统计学意义(P<0.05);化疗2个疗程后完全缓解患者血清SOD水平[(158.74±29.49)u/mL]较化疗前[(149.11±27.17)u/mL]明显提高(P<0.05)。结论 DLBCL患者血清SOD水平降低,且其水平与IPI评分、临床分期、化疗效果有关;SOD可能参与了DLBCL的发病过程。

Objective To explore the change and significance of serum superoxide dismutase（SOD）in patients with diffuse large B-cell lymphoma（DLBCL）.Methods The serum SOD levels were detected in 57 patients with DLBCL（observation group）and 40 patients with reactive hyperplasia of lymph node（control group）to analyze the relationship of serum SOD level with clinical pathological parameters and chemotherapeutic result.Results The serum SOD level was significantly lower in observation group（（149.11±27.17）u/mL）than that in control group（（160.13±22.98）u/mL）（P〈0.05）.There were no significant differences in SOD levels in different genders and ages in observation group（P〉0.05）,and there were significant difference in SOD levels in different international prognostic index scores and clinical stages（P〈0.05）.The serum SOD level after 2courses of treatment in complete remission patients（（158.74±29.49）u/mL）was significantly higher than that before chemotherapy（（149.11±27.17）u/mL）（P〈0.05）.Conclusion The serum SOD level decreases in DLBCL patients,and is correlated with international prognostic index score,clinical staging and chemotherapeutic result,indicating that SOD participates in the pathogenesis of DLBCL.