细胞间黏附分子-1与冠状动脉慢血流的相关性

Correlation of serum intercellular adhesion molecule-1 and coronary slow flow

目的探讨细胞间黏附分子-1（intercellular adhesion molecule-1,ICAM-1）和冠状动脉慢血流（coronary slow flow,CSF）的相关性。方法因胸痛行冠状动脉造影且未发现明显病变者186例,根据校正的TIMI帧数（correlated TIMI frame count,CTFC）法分为CSF组78例及对照组108例。比较2组一般资料;采用ELISA测定患者血浆ICAM-1水平,分析CSF的危险因素。结果 CSF组血浆ICAM-1[（336.3±75.6）μg/L]高于对照组[（294.4±65.5）μg/L]（P〈0.05）,2组年龄、性别,合并高血压、高脂血症比率比较差异均无统计学意义（P〉0.05）;多因素logistic回归分析显示,在调整其他心血管危险因素影响后,ICAM-1水平升高（OR=3.449,95%CI：1.687~9.234,P=0.000）是发生SCF的独立危险因素。结论 ICAM-1在CSF发生中有重要作用,其水平升高可能是CSF发生的危险因素之一。

Objective To investigate the correlation between serum level of intercellular adhesion molecule-1（ICAM-1）and the risk of coronary slow flow（CSF）.Methods A total of 186 patients receiving coronary angiography（CAG）due to chest pain were divided into CSF group（n=78）and control group（n=108）according to corrected TIMI frame count（CTFC）.The general data were compared between two groups,and ICAM-1 level was detected by ELISA method to analyze the risk factors for CSF.Results The level of ICAM-1 was significantly higher in CSF group（（336.3±75.6）μg/L than that in control group（（294.4±65.5）μg/L））（P〈0.05）.There were no significant differences in the age,gender,incidence of hypertension and incidence of hyperlipidemia between two groups（P〉0.05）.Multivariate logistic regression analysis showed high ICAM-1 level（OR=3.449,95%CI：1.687 to 9.234,P=0.000）was the independent risk factor for CSF.ConclusionICAM-1 may play a key role in the development of CSF and high level of ICAM-1 is one of the risk factors for CSF.