三橘荔核汤对CAP/CPPS患者前列腺液IL-1β、TNF-α表达的影响

Influence of Sanju Lihe Decoction(三橘荔核汤) on Expression of IL-1βand TNF-α in Succus Prostaticus of CAP/CPPS Patients

目的:观察三橘荔核汤对慢性非细菌性前列腺炎/慢性盆腔疼痛综合征(CAP/CPPS)患者前列腺液IL-1β、TNF-α表达的影响。方法:将符合CAP/CPPS(气滞血瘀证)诊断标准的患者70例,随机分为治疗组和对照组各35例。治疗组采用三橘荔核汤口服,对照组采用前列腺汤口服,两组均连续治疗1个月。观察两组患者临床疗效、NIH-CPSI积分及前列腺液中细胞因子IL-1β、TNF-α水平的变化。结果:两组治疗后综合疗效比较,差异有统计学意义(P<0.05),治疗组优于对照组;治疗后两组NIH-CPSI积分比较,治疗组低于对照组,差异有统计学意义(P<0.05);治疗后两组IL-1β、TNF-α的表达比较,治疗组低于对照组,差异均有统计学意义(P<0.05)。结论:三橘荔核汤治疗CAP/CPPS有较好疗效,其作用机制可能与调控炎症细胞因子IL-1β、TNF-α的表达相关。

Objective： To observe the influence of Sanju Lihe Decoction （三橘荔核汤, SJLHD） on expression of IL-1β and TNF-αin suecus prostaticus of CAP/CPPS patients. Methods： The 70 cases of patients meeting the diagnostic criteria of CAP/CPPS （Qi stagnation and blood stasis） were randomly divided into treatment and control groups, 35 cases in each. Patients were given SJLHD in treatment group and Qianliexian Decoction （前列腺汤） in control group. The treatment lasted lmonth.The clinical efficacy, NIH-CPSI scores and change of IL-1β and TNF-α in suceus prostatieus were observed. Results： The comparison of comprehensive efficacy between the two groups showed statistical significance （P〈0.05）; and the comparison of NIH-CPSI scores between the two groups showed statistical significance （P〈0.05）; the comparison of expression of IL-1α and TNF-β between the two groups showed statistical significance （P〈0.05）. Conclusion： SJLHD can provide obvious clinical efficacy for CAP/CPPS, the mechanism of which may related to the regulation of expression of IL-1α and TNF- β and immune function.