CEA和SCC联合检测对肺癌诊断的临床价值

Clinical value of combined detection of of SCC and CEA in the diagnosis of lung cancer

目的探讨鳞状细胞癌相关抗原(CEA)、癌胚抗原(SCC)联合检测对肺癌诊断的临床价值。方法选取于2015年1月至2016年4月高州市人民医院呼吸科接收的382例就诊者,其中172例确诊为肺癌(肺癌组),110例肺良性病变患者(肺良性病变组),100例为健康体检者(健康对照组),均采用化学发光法检测入选者血清中SCC、CEA水平,对比CEA、SCC单独检测与CEA和SCC联合检查对肺癌的诊断效能。结果肺癌组血清CEA、SCC水平均明显高于肺良性病变组和健康对照组,肺良性病变组高于健康对照组,且差异均有统计学意义(P<0.05);CEA在腺癌中的水平最高,与鳞癌、小细胞肺癌比较,差异具有统计学意义(P<0.05);SCC在鳞癌中水平最高,与小细胞肺癌、腺癌比较,差异具有统计学意义(P<0.05);单独CEA检测肺癌的灵敏度高于单独SCC检测,差异具有统计学意义(P<0.05),而CEA和SCC联合检测的敏感度、阴性预测值则均高于单独CEA、SCC检测,差异具有统计学意义(P<0.05)。结论 CEA、SCC可用于不同组织类型的肺癌鉴别,并且两者联合具有互补性,可提高阳性诊断率,便于肺癌早期发现、早期治疗,具有推广价值。

Objective To explore the clinical value of combined detection of SCC and CEA in the diagnosis of lung cancer.Methods 382 cases from January 2015 to April 2016 in the respiratory department of our hospital were selected in this survey.Among which 172 cases with lung cancer,110 cases with benign lung diseases and 100 healthy person.The CEA and SCC content in serum of all these cases were determined by chemical chemiluminescence,and the diagnostic efficacy of lung cancer by CEA or SCC alone and CEA and SCC combined examination was compared.Results In lung cancer group,the serum levels of CEA and SCC content were significantly higher than those of the normal control group and lung benign disease group（P〈0.05）,and benign lung disease group were significantly higher than that of the normal control group（P〈0.05）.and compared with squamous cell carcinoma and small cell lung cancer,CEA has the highest content in adenocarcinoma（P〈0.05）.Meanwhile,the content of SCC in squamous cell carcinoma was obviously higher than that of small cell lung cancer and adenocarcinoma（P〈0.05）,The sensitivity of CEA was significantly higher than that of SCC（P〈0.05）,and the sensitivity and negative predictive value in combined detection group was significantly higher than that of CEA or SCC（P〈0.05）.Conclusion SCC and CEA could be used to identify different types of lung cancer,and the combination of the two methods could improve the positive diagnosis rate,facilitate the early detection of lung cancer,early treatment,has the promotion value.