不同剂量阿托伐他汀对急性脑梗死患者颈动脉粥样硬化斑块的治疗效果

Influence of different dose of atovastatin on carotid atherosclerotic plaques of patients with acute cerebral infarction

目的探讨不同剂量阿托伐他汀对急性脑梗死患者动脉粥样硬化斑块的影响。方法选取2014年1月至2015年1月于我院进行治疗的合并颈动脉粥样硬化斑块的急性脑梗死患者122例作为研究对象,根据随机数字表法将其随机分为A组(41例)、B组(41例)及C组(40例)。A组患者给予常规治疗,B组患者在常规治疗上加用小剂量阿托伐他汀,C组患者在常规治疗基础上加用大剂量阿托伐他汀。比较三组患者治疗前后血脂水平、颈动脉粥样硬化斑块面积及不良反应发生情况。结果 B、C两组患者治疗后TC、TG及LDL均较治疗前明显下降,HDL较治疗前明显升高,且均较A组有显著差异(P<0.05)。治疗前三组患者斑块面积无显著差异,治疗后C组斑块面积明显下降(P<0.05),A、B两组与治疗前比较差异不显著(P>0.05)。三组患者均无严重不良反应发生。结论阿托伐他汀可显著改善急性脑梗死患者颈动脉粥样硬化,以大剂量阿托伐他汀疗效更佳。

Objective To explore the influence of different dose of atovastatin on carotid atherosclerotic plaques of patients with acute cerebral infarction. Methods From January 2014 to January 2015, 122 patients with acute cerebral infarction and carotid atherosclerotic plaques accepted in our hospital were selected and randomly divided into group A （41 cases）, group B （41 cases） and group C （40 cases）. Group A was given normal treatment, group B received small dose of atovastatin, group C was given large dose of atovastatin. The lipid levels, area of carotid atherosclerotic plaques and adverse reactions of the three groups were compared. Results The TC, TG and LDL expression level of group B and C after treatment decreased and HDL expression level increased compared with before treatment and group A with statistically significant difference （P〈0.05）. The area of carotid atherosclerotic plaques before treatment of the three groups had no statistically difference significance. The area of carotid atheroselerotic plaques of group C after treatment was obviously decreased （P〈0.05）, while group A and B had no statistically significant difference （P〉0.05）. There was no serious adverse reactions of the three groups. Conclusion Atovastatin can improve the carotid atherosclerotic plaques of patients with acute cerebral infarction. Large dose of atovastatin can work better.