中医益气活血法治疗气虚血瘀型房颤疗效观察

Clinical efficacy observation on qi-supplementing and blood-activating method for treatment of qi deficiency and blood stasis type atrial fibrillation

目的分析中医益气活血法治疗气虚血瘀型房颤患者的临床效果。方法选择2015年1月至2016年3月我院收治的气虚血瘀型房颤患者80例作为研究对象,随机分为对照组与观察组,每组40例。对照组患者给予控制心率、抗血小板、抗凝等常规治疗。观察组患者在对照组的基础上加用益气活血中药汤剂。治疗后,比较两组患者的中医综合证候疗效、不良反应发生情况、血浆凝血酶原时间(PT)、部分凝血活酶时间(APTT)、血浆纤维蛋白原(FIB)的变化。结果治疗后,观察组患者的APTT、PT及FIB水平均明显优于对照组,差异均具有统计学意义(P<0.05);观察组中医证候总有效率为85.0%,高于对照组的52.5%(P<0.05);观察组不良反应发生率明显低于对照组(P<0.05)。结论益气活血法用于治疗气虚血瘀型房颤患者,疗效显著,能够明显改善中医症候疗效,有效提高APTT及PT水平及降低FIB水平,值得临床应用推广。

Objective To analyze the clinical effect of qi-supplementing and blood-activating method in treatment of qi deficiency and blood stasis type atrial fibrillation. Methods Eighty cases of patients with qi deficiency and blood stasis type atrial fibrillation in our hospital from January 2015 to March 2016 were selected and randomly divided into control group and observation group, with 40 cases in each group. The control group received conventional therapy including control heart rate, antiplatelet, anticoagulant therapy, while the observation group received qi-supplementing and blood-activating decoction on the basis of the control group. The TCM syndrome curative effect, adverse reactions, changes of PT, APTT and FIB levels between the two groups after the treatment were compared. Results After the treatment, the level of APTT, PT and FIB in the observation group were significantly better than those in the control group, the differences were statistically significant （P〈0.05）. The TCM syndrome curative effect of the observation group was 85.0%, which was higher than 52.5% of the control group （P〈0.05）. The adverse reaction rate of the observation group was lower than that of the control group （P〈0.05）. Conclusion For treating qi deficiency and blood stasis type atrial fibrillation, qi-supplementing and bloodactivating method has significant effect, which can improve the efficacy of TCM symptoms, effectively improve the levels of APTT and PT, and reduce the level of FIB. It is worthy of clinical application.