摘要
目的对抗银屑病新药艾托莫德原料药中的7种有关物质Imp-A^Imp-G进行结构鉴定。方法利用高效液相色谱-四级杆线性离子阱质谱联用法(HPLC-QTrap-MS)推测各有关物质的结构,高效液相色谱-四级杆飞行时间质谱联用法(HPLCQTOF/MS)技术快速确证各结构的相对分子质量及分子组成。结果获得了艾托莫德原料药中的7种有关物质Imp-A^ImpG的相对分子质量及结构式。结论方法快速、简便,为原料药的杂质解析提供了良好的思路,并为创新药物艾托莫德的有关物质研究及质量控制提供了有意义的实验数据和参考依据。
OBJECTIVE To identify the related substances in aituomode bulk drug. METHODS HPLC-QTrap-MS and HPLC- QTOF-MS were used to determine seven kinds of related substances denoted by Imp-A to Imp-G. RESULTS The structures and molecular weights of the related substances in aituomode were identified. CONCLUSION The method is simple and accurate, providing a good idea for the identification of the related substances in bulk drugs. The experimental data are valuable to the determination of the related substances and quality control of aituomode.
出处
《中国药学杂志》
CAS
CSCD
北大核心
2017年第1期68-71,共4页
Chinese Pharmaceutical Journal
基金
中央级公益性科研院所基本科研业务费专项基金资助项目(2015CX09)
