高通量透析联合血液灌流对尿毒症患者不宁腿综合征的疗效观察

The Efficacy Observation of High Flux Dialysis Combined with Hemoperfusion on Restless Legs Syndrome in Uremic Patients

目的:对比研究常规血液透析、高通量透析、高通量透析联合血液灌流对不宁腿综合征(RLS)治疗的效果。方法:按抽签法随机将入选的30例患者分为三组,A组采用常规血液透析,B组采用高通量透析,C组采用高通量透析联合血液灌流,各10例,疗程均为3个月。治疗前后分别检测并比较三组患者的甲状旁腺激素(i PTH)、β_2-微球蛋白(β_2-MG)及不宁腿综合征评分。结果:治疗前,三组患者的i PTH、β_2-MG及RLS评分比较,差异无统计学意义(P>0.05)。治疗后,A组患者的RLS评分与治疗前比较,显著降低,差异有统计学意义(P<0.05);B组、C组的RLS评分、i PTH、β_2-MG与治疗前比较,均显著降低,差异均有统计学意义(P<0.05)。C组患者的i PTH、β_2-MG、RLS评分下降幅度最明显,B组次之,A组最低,组间比较差异均有统计学意义(P<0.05)。结论:相对于常规血液透析与高通量透析,高通量透析联合血液灌流对尿毒症血液透析患者的RLS症状和生活质量的改善效果更为显著,临床应用价值更大。

Objective： To compare the effects of routine hemodialysis, high flux dialysis and high flux dialysis combined with hemoperfusion on the treatment of restless legs syndrome （ RLS ） .Method： According to the ballot method, 30 cases were randomly diyided into three groups, A group used conventional hemodialysis, B group used high flux dialysis, C group used high flux dialysis combined with hemoperfusion, 10 cases in each group, the course of treatment were 3 months.Before and after treatment, the three groups of patients with parathyroid hormone （ iPTH ）, β2-microspheres （ β2-MG ） and restless legs syndrome score were detected and compared.Result： Before treatment, the three groups of patients with iPTH, 13 2-MG,and RLS score comparison, the difference was not statistically significant （P〉0.05） .After treatment, the RLS score of A group was significantly lower than that before treatment, the difference was statistically significant （ P〈0.05 ）, the RLS score, iPTH, ~ 2-MG of B group and C group were significantly reduced, compared with before treatment, the differences were statistically significant （ P〈0.05 ） .The iPTH, 13 2-MG, RLS score in the C group decreased significantly, the second was B group, A group was the lowest, there were statistically significant differences between the three groups （ P〈0.05 ） .Conclusion： Compared with conventional hemodialysis and high flux dialysis, high flux dialysis combined with hemoperfusion on RLS symptoms and quality of life in patients with uremia hemodialysis is more significant, and the clinical application value is greater.