持续静脉泵入咪达唑仑治疗小儿癫痫持续状态的疗效观察及护理

Clinical Observation and Nursing Care of Continuous Intravenous Infusion of Midazolam in the Treatment of Children with Epilepsy

目的:总结持续静脉泵入咪达唑仑治疗小儿癫痫持续状态的临床效果与护理。方法:选取本院2014年4月-2015年4月收治的64例小儿癫痫持续状态患儿为研究对象,按照患儿收治顺序将其随机分为对照组和试验组,各32例。对照组患儿采用丙戊酸钠和5%葡萄糖溶解安定辅助治疗,且配合传统的常规护理;试验组患儿采用持续静脉泵入咪达唑仑进行治疗,且进行全面护理干预。对比两组患儿的发病时间、发病间隔、治疗总有效率、不良反应发生情况及患儿家属对护理工作满意度。结果:试验组患儿发病持续时间明显短于对照组,发病间隔长于对照组,差别均有统计学意义(P<0.05);试验组患儿治疗总有效率为93.75%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);试验组患儿不良反应发生率为18.75%,低于对照组的62.50%,差异有统计学意义(P<0.05);试验组患儿家属对护理工作满意度为96.88%,高于对照组的81.25%,差异有统计学意义(P<0.05)。结论:临床采用咪达唑仑治疗小儿癫痫持续状态,加之恰当的护理干预,能够明显减少患儿的不良反应,提高治疗效果,具有临床使用和推广的价值。

Objective： To summarize the clinical effect and nursing of continuous intravenous infusion of Midazolam in the treatment of children with epilepsy.Method： 64 children with status epilepticus in our hospital from April 2014 to April 2015 were selected as the research objects, according to the order of children, they were randomly divided into the control group and the experimental group, each of 32 cases.The control group was treated with Sodium Valproate and 5% Glucose Solution dissolve Valium therapy, and combined with conventional nursing care, the experimental group was treated with continuous intravenous infusion of Midazolam, and the comPrehensive nursing intervention was carried out.The time of onset, interval of onset, total effective rate, incidence of adverse reactions and family members＇ satisfaction on nursing care of the two groups were compared. Result： The time of onset of the experimental group was significantly shorter than the control group, the interval of onset was longer than the control group, the differences were statistically significant （ P〈0.05 ） .The total effective rate of the experimental group was 93.75%, significantly higher than 75.00% of the control group, the difference was statistically significant （P〈0.05） .The incidence of adverse reactions in the experimental group was 18.75%, lower than 62.50% of the control group, the difference was statistically significant （ P〈0.05 ） .The family members of the experimental group of nursing work satisfaction was 96.88%, higher than 81.25% of the control group, the difference was statistically significant （P〈0.05） .Conclusion： Clinical use of Midazolam in the treatment of children with epilepsy status, combined with appropriate nursing intervention, can significantly reduce the adverse reactions of children, improve the treatment effect, has the value of clinical use and promotion.