白介素-31与特应性皮炎的相关性研究进展

Recent Research Progress of the Correlations between Interleukin-31 and Atopic Dermatitis

白介素-31(interleukin-31,IL-31)是新近发现的一种与皮肤慢性炎症、瘙痒相关细胞因子。特应性皮炎(atopic dermatitis,AD)、慢性自发性荨麻疹、变应性接触性皮炎、结节性痒疹、皮肤原发性淋巴瘤和肥大细胞增多症的患者表现出血清中IL-31水平升高和皮肤中IL-31 m RNA增加,而且血清中IL-31水平与特应性皮炎的活动性相关。在本综述中,笔者总结IL-31与特应性皮炎的相关性研究进展,通过了解其受体和信号通路可以更好地了解AD的发病机制,为开发出新的治疗方法提供思路。

Interleukin-31 （ IL-31 ）is a newly discovered cytokine associated with chronic skin inflammation and pruritus.Patients with atopic dermatitis, chronic spontaneous urticaria, allergic contact dermatitis, prurigo nodularis, primary cutaneous lymphoma and mastocytosis exhibit increased serum levels of IL-31 protein and elevated IL-31 mRNA in the skin.And, IL-31 serum levels have been reported to be correlate with disease activity in atopic dermatitis.In the present review, we particularly focus on studies investigating the role of IL-31 in atopic dermatitis.We conclude that growing knowledge about IL-31, its receptors and signaling pathways serve to better understand the pathogenesis of atopic dermatitis and may lead to the development of novel treatment approaches.