肝功能指标正常慢性乙型肝炎患者的肝功能与HBV-DNA病毒载量关系研究

A study on the relationship between HBV-DNA in viral load and liver function in chronic hepatitis B patients with normal liver function

目的:探讨肝功能指标正常慢性乙型肝炎患者的肝功能与HBV-DNA病毒载量的相关性。方法:收集本院2014年12月-2015年12月收治的74例慢性乙型肝炎患者作为实验组,选择同期入院查体的70例健康体检者作为对照组,检测两组受试者血清丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、白蛋白/球蛋白比值(A/G),直接胆红素(DBi)、间接胆红素(IBi)、总胆红素(TBi)等肝功能指标的表达水平,测定两组患者HBV-DNA病毒载量,观察肝功能指标与HBV-DNA病毒载量的关系。结果:实验组患者血清AST、ALT、DBi、IBi、TBi水平高于对照组,A/G比值低于对照组,差异均存在统计学意义(P<0.05);实验组患者血清ALT、IBi、TBi表达水平与HBV-DNA病毒载量呈正相关(r=0.392,P<0.01;r=0.310,P<0.01;r=0.450,P<0.01),AST、DBi、A/G与HBV-DNA病毒载量无相关性(r=0.091,P>0.05);对照组体检者HBV-DNA病毒载量为阴性,与血清肝功能指标无相关性。结论:肝功能指标正常范围内的慢性乙型肝炎患者血清肝功能指标异于正常人群,丙氨酸氨基转移酶、总胆红素、间接胆红素表达水平与HBV-DNA病毒载量呈正相关,是反映肝细胞损害的相对敏感指标。

Objective： To evaluate the relationship between liver function in chronic hepatitis B patients with normal liver function and HBV-DNA in viral load. Methods： 74 patients were selected as experiment group; 70 healthy person were selected as control group. Results： The patients＇ serum AST, ALT, DBi, IBi, TBi level were higher than the control group, A/G ratio was lower than the control group （P〈0.05）; the patients＇ serum ALT, IBi, TBi expression levels were positively correlated with HBV-DNA viral load （r=0.392, P〈0.01; r=0.31, P〈0.01; r=0.45, P〈0.01）, AST, DBi, and A/G have no correlation with the HBV-DNA viral load （r=0.091,P〉0.05）; HBV-DNA viral load in the control group is negative, no correlation with serum liver function. Conclusion： Normal liver function indexes in patients with chronic hepatitis B in serum is different from normal people; alanine aminotransferase, total bilirubin and indirect bilirubin levels were positively correlated with HBV-DNA in viral load, reacted relatively sensitive indicator of liver cell damage.