加味柴胡疏肝散治疗抑郁症疼痛

Modified Chaihu Shugan powder in treating depression pain

目的:观察中西药联合治疗以疼痛为主诉的抑郁症临床疗效。方法:选取80例符合诊断标准以疼痛为主诉的抑郁症患者,随机分为两组,对照组和治疗组各40例。对照组采用盐酸度洛西汀肠溶片60 mg/d治疗,治疗组在对照组基础上加用加味柴胡疏肝散治疗,分别在治疗前、治疗4周、8周、12周采用汉密顿抑郁量表24项量表(HAMD-24)及视觉模拟评分法(VAS)评定疼痛症状。结果:两组患者在治疗4周时,两组差异有统计学意义(P<0.05);在治疗8周、12周时差异明显(P<0.01),在治疗12周结束时用调查法统计残留症状,统计学处理后(P<0.01)。结论:中西药联合治疗以疼痛为主诉的抑郁症疗效好、不良反应小、残留症状少,值得推广。

Objective： To observe the clinical effect of combined traditional Chinese and western medicine in the treatment of depressive disorder with the chief complaint of pain symptom. Methods： 80 patients with the chief complaint of pain symptom and met criteria for depressive disorder were selected randomly and divided into two groups, namely the control group and the treatment group, with 40 cases in each group. The control group was treated with Duloxetine hydrochloride enteric capsule alone, 60 mg/d while the treatment group received Modified Chaihu Shugan powder. Both groups were respectively assessed pain symptoms with Hamilton depression scale-24 scale （HAMD-24） and visual analogue scale （VAS） at the starting point, 4 weeks, 8 weeks, and 12 weeks after treatment. Results： Statistically, the two groups of patients showed difference 4 weeks after treatment （P〈0.05）, and difference was significant 8 weeks, 12 weeks after treatment （P〈0.01）. At the end of 12 weeks of the treatment, investigation method was applied to estimate residual symptoms （P〈0.01）. Conclusion： The combined traditional Chinese and western medicine showed better clinical effect in the treatment of depressive disorder with the chief complaint of pain symptom, it had fewer side effects and less residual symptoms, and deserved the clinical promotion.