丙泊酚和右美托咪定对于重症监护病房患者的镇静效果对比观察

Contrast observation of sedative effect of propofol and dexmedetomidine on ICU patients

目的:对比分析应用丙泊酚与右美托咪定对重症监护病房患者镇静的临床效果及安全性,总结应用体会。方法:选取我院重症监护病房(ICU)2013年11月—2015年10月收治的142例重症患者,随机分为两组,每组71例,分别给予丙泊酚和右美托咪定进行镇静。对比分析两组患者达到镇静满意的时间、停药后唤醒时间及不良反应发生率等指标。结果:丙泊酚组达到镇静满意时间及停药后唤醒时间均显著短于右美托咪定组,两组比较差异具有统计学意义(P<0.05);丙泊酚组患者的药物不良反应主要以注射部位疼痛、血压下降、呼吸抑制为主,而右美托咪定组的药物不良反应主要以血压下降、心动过缓及口干为主,两组比较差异具有统计学意义(P<0.05)。结论:丙泊酚和右美托咪定均是重症患者的有效镇静剂,但是由于其不良反应不同,因此在用药时要严格把握指征,密切关注患者生命体征变化,确保患者生命安全。

Objective： To compare and analyze the clinical effect and safety of sedative effect ofpropofol and dexmedetomidine on ICU patients and to summarize the application experience. Methods： 142 cases of ICU patients treated in our hospital from November 2013 to October 2015 were randomly divided into two groups, with 71 cases in each group and received propofol and dexmedetomidine for sedation respectively. The indexes of the time of sedation satisfaction, the wake-up time after discontinuation and the incidence of adverse reactions of two groups of patients were compared and analyzed. Results： The time of sedation satisfaction and the wake-up time after discontinuation of propofol group was significantly shorter than that of the dexmedetornidine group, the difference of two groups was of statistical significance （P 〈 0.05）; The main adverse drug reactions of propofol group were injection site pain, decreased blood pressure and respiratory depression and the main adverse drug reactions of dexmedetomidine group were decreased blood pressure, bradycardia and dry mouth, the difference of two groups was of statistical significance （P 〈 0.05）. Conclusion： Propofol and dexmedetomidine were both effective sedation on ICU patients, but because of their different adverse reactions, the indications of medication should be strictly controlled and close attention should be paid to patients on the change of vital signs to ensure the life safety of patients.