剪切体蛋白PRPF8的研究进展

Study on spliceosome of PRPF8

真核生物中,mRNA前体的可变剪切是一个重要过程,在这过程中剪切体蛋白起到重要的作用。PRPF8是剪切体的核心蛋白,它的突变可引起一些模型细胞的死亡,并且与疾病的发生有重要的关系。

In eukaryotes, alternative splicing of mRNA precursors is an important process, which plays an important role in this process. PRPF8 is the core protein of splicing, the mutation of which can cause the death of model cell, and it has an important relationship with the occurrence of the disease.