果酸联合口服氨甲环酸治疗黄褐斑临床观察

The clinical observation of Glycolic Acid and Tranexamic Acid for Chloasma treatment

目的:探讨果酸联合口服氨甲环酸治疗黄褐斑的疗效。方法:将69例黄褐斑患者随机分成3组,每组各23例。治疗组果酸联合口服氨甲环酸治疗,对照1组单纯果酸治疗,对照2组单纯口服氨甲环酸。果酸每2周治疗1次,治疗3个月。口服氨甲环酸片0.25g一日两次,连服3个月;结果:治疗组有效率为65.2%,对照1组为30.4%,对照2组为39.1%,差异有统计学意义(P<0.05)。结论:果酸联合口服氨甲环酸治疗黄褐斑疗效优于两者单独应用。

Objective： To explore the efi%acy for treating chloasma by Glycolic Acid Peeling with Tranexamic Acid. Methods：Sixty-Nine patients were enrolled in treatment group,control 1 and 2 group randomly. Twenty-Three patients of treatment group were treated twice a month for three months by Glycolic Acid combining with Tranexamic Acid 0.25g two times a day for three months. Twenty-Three patients of control 1 group were treated by Glycolic Acid and the 23 patients of control 2 group taking Tranexamic Acid only respectively.Results：The markedly effective rate of treatment group 65.2% and that control 1 group and control 2 group was 30.4% and 39.1% respectively.The markedly effective rate of control 1 group and control 2 group was significantly lower than that of treatment group（P〈0.05）.Conclusion：The Glycolic Acid Peeling combining with Tranexamic Acid is more effective in treatment of chloasma than the Glycolic Acid and Tranexamic Acid respectively.