摘要
目的了解南京地区妊娠中晚期孕妇维生素D水平,并分析其与年龄、孕周、孕前体质量指数(BMI)以及季节变化之间的关系,为临床开展维生素D检测及补充提供依据。方法收集2015年1至12月在南京医科大学附属妇产医院建卡并定期产检的880名妊娠21~36周孕妇为研究对象,酶联免疫吸附法(ELISA)测定血清25羟-维生素D[25-(OH)D]浓度。结果孕妇血清维生素D水平为(42.03±19.22)nmol/L,维生素D充足者仅42例(4.77%)。季节变化对维生素D水平有影响(P=0.0164),夏季[(44.61±23.57)nmol/L]和秋季[(43.43±19.31)nmol/L]高于春季[(39.68±16.91)nmo]/L]和冬季[(39.65±13.36)nmol/L](均P〈0.05)。不同孕周间血清维生素D水平差异无统计学意义(P=0.9294)。不同年龄组间孕妇血清维生素D水平差异有统计学意义(P=0.0383)。维生素D和孕前BMI间无相关性。结论维生素D作为孕妇以及胎儿生长发育的必要营养素,营养状况不容乐观,建议积极开展维生素D检测。
Objective To analyze the serum level of 25-hydroxy vitamin D [ 25-(OH) D ] in pregnant women in Nanjing and its relationship with age, gestational week, pre-pregnaney body mass index (BMI) and season, so as to provide some guidance on clinical application of vitamin D measurement and supplementation. Methods 880 pregnant women (in 21 -36 gestational weeks) regularly visiting antenatal clinic in Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University were selected from January to December 2015. Their serum 25-(OH)D concentrations were measured by enzyme-linked immunosorbent assay (ELISA). Results The mean serum 25- (OH) D concentration in these pregnant women was ( 42.03 ± 19. 22 ) nmol/L and sufficient in only 42 (4. 77% ). Vitamin D levels showed seasonal variation (P =0. 0164), with the levels in summer [ (44. 61 ±23.57) nmol/L] and autumn [ (43.43 ± 19. 31) nmol/L] being higher than spring [ (39. 68 ± 16. 91 ) nmol/L] and winter [ (39. 65 ± 13.36) nmol/L]. There was no statistically significant difference in serum vitamin D level among different gestational weeks ( P = 0. 929 4 ). There was statistically significant differenee in serum vitamin D level among different age groups ( P = 0. 038 3 ). Vitamin D level was not associated with pre-pregnaney BMI. Conclusions Vitamin D defieieney is highly prevalent among pregnant women in Nanjing. We suggest vitamin D testing be carried out more actively.
出处
《中华临床营养杂志》
CAS
CSCD
2016年第6期354-358,共5页
Chinese Journal of Clinical Nutrition
基金
南京市卫生局一般课题(YKK13139)
关键词
维生素D
孕妇
Vitamin D
Pregnant women