不同抗萎缩运动模式对泛素蛋白酶体亚基及基因表达的影响

Effects of Different Anti-Atrophy Movement Patterns of the Ubiquitin-Proteasome Subunit and Gene Expression

骨骼肌萎缩是由于肌肉蛋白质降解或合成受阻,打破机体内肌蛋白平衡状态,从而引起泛素蛋白酶体亚基及基因表达量的变化,使肌肉环状指基因1、肌肉萎缩盒F基因表达升高,促进ATP-泛素-蛋白酶体途径的进一步激活,最终导致肌萎缩现象加重。研究发现,运动可通过调节泛素蛋白酶体相关因子的表达水平,进而抑制MuRF1、MAFbx/Atrogin-1 mRNA的表达,从而改善肌萎缩症状;而不同运动模式对于改善肌萎缩效果则不尽相同。本文主要通过对不同运动模式而产生的效果逐一进行分析,并对其中的关键性靶基因表达量的变化进行描述,对比分析不同运动模式的调节状况;同时对FOXO、Akt、AMPK等肌萎缩相关因子调控通路进行介绍。由此寻求最有效的运动介导模式,以对如何改善肌萎缩症状提供更有效的方式。

Skeletal muscle atrc of muscle protein degradation phy is due to the obstacle or synthetic, breaking machine in muscle protein balance state, causing the ubiquitin proteasome subunit and gene expression chan- ges, making muscle ring finger 1 and muscle atrophy Fbox expression increased, promoting ATP-ubiquitin-proteasome pathway further activation, eventually leading to muscle atrophy aggravated. The study found that move- ment can regulate the expression of ubiquitin proteasome related factors, then inhibit the expression of MuRF1, MAFbx/Atrogin- 1 mRNA to improve the symptoms of muscle atrophy. While different movement patterns to im- prove muscle contraction effect is not the same. This paper mainly through the effect of different motion patterns ana- lyzed one by one, and described the key target genes ex- pression, compared and analyzed different movement pat- terns of regulation. Meanwhile FOXO, Akt and AMPK re- lated muscle atrophy and other factors are described regu- latory pathway. Seeking the most effective movement mediated pattern to improve the symptoms of amyotrophic to provide a more efficient way.