非吸烟与吸烟肺癌患者的围手术期指标比较研究

Study on the comparison of operation period indexes in lung cancer between smokers and non-smokers

目的研究非吸烟肺癌患者与吸烟肺癌患者在手术前后相关临床指标的区别。方法回顾性分析2012年1月至2015年10月某院胸外科手术治疗的肺癌患者411例,均经病理学证实。其中非吸烟者(非吸烟组)123例,男49例,女74例,平均年龄63.6岁;吸烟者(吸烟组)216例,男174例,女42例,平均年龄60.6岁;另72例吸烟后又戒烟患者不在研究范围内。比较分析两组患者围手术期相关临床指标的区别,包括肺功能、淋巴结转移率、组织分化程度、术后肺部感染发生率、引流液大于150mL的天数、术后住院天数等。结果全组患者均无围手术期死亡及严重并发症。非吸烟组与吸烟组比较,在肺功能方面前者明显优于后者;淋巴结转移率前者略高,但差异无统计学意义;组织分化程度上前者高分化型比例高于后者,而低分化型比例明显低于后者,差异均有统计学意义。非吸烟组患者术后肺部感染发生率低于吸烟组,引流液大于150mL天数前者少于后者,术后住院天数前者少于后者,差异均有统计学意义。结论非吸烟肺癌患者较吸烟肺癌患者,肺功能更好,组织分化程度更高,术后肺部感染发生几率更低,恢复更快。

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