桂林市老年人群高尿酸血症的患病情况及危险因素分析

Morbidity and risk factors of hyperuricemia in elderly people from Guilin City

目的了解桂林市老年人群高尿酸血症(HU)的患病情况,并分析其危险因素。方法抽取1 481例60岁以上的桂林市老年人,对其进行体格检查、生化指标和肝脏超声检查。将HU人群作为高尿酸组,同时选择性别、年龄相匹配的相同例数尿酸正常人群作为对照组,比较两组的临床生化指标、非酒精性脂肪肝者(NAFLD)发生情况等;采用多因素非条件logistic回归分析影响HU的危险因素。结果 1 481例桂林市老年人群中HU 330例,总患病率为22.28%,其中男性为20.56%(169/822),女性为24.43%(161/659),男女HU患病率比较差异无统计学意义(P>0.05)。HU组舒张压、体重指数(BMI)、TG、LDL-C、NAFLD比例均高于对照组,而HDL-C低于对照组(均P<0.05)。TG≥1.8 mmol/L、BMI≥24 kg/m2、NAFLD、高血压均为HU的独立危险因素(P<0.05)。结论桂林市老年人群HU患病率较高,呈现合并代谢综合征的特点,TG≥1.8 mmol/L、BMI≥24 kg/m2、NAFLD、高血压均为HU的独立危险因素。

Objective To investigate the prevalence of hyperuricemia in the elderly people from Guilin City, and to analyze its risk factors. Methods A total of 1 481 elderly people over 60 years old from Guilin City were enrolled in this survey. Physical examination, biochemical tests, and hepatic ultrasonography were performed. People with hyperuricemia was assigned to hyperuricemia group, with the same amount of age and sex-matched people of normal uric acid level as control group. Clinical and biochemical indices, incidence of nonalcoholic fatty liver disease（NAFLD） were compared between the two groups. The risk factors for hyperuricemia were analyzed using multivariate unconditional logistic regression analysis. Results Of 1 481 elderly people from Guilin City, hyperuricemia occurred in 330 cases,with a total mobility of 22.28%. The mobility of hyperuricemia in the male and the female were 20.56% （169/822） and 24.43% （ 161/659 ） respectively, but without statistical difference （ P 〉 0.05 ）. The diastolic blood pressure, body mass index （ BMI ） , TG, LDL-C, and the proportion of patients with NAFLD were higher,and HDL-C was lower in the byperuricemia group compared to the control group （ P 〈0.05 ）. TG≥1.8 mmol/L, BMI≥24 kg/m^2, NAFLD and hypertension were the independent risk factors for hyperuricemia（ P 〈 0.05 ）. Conclusion The morbidity of hyperuricemia is high, with a feature of combined metabolic syndrome in the elderly people from Guilin City. TG≥1.8 mmol/L,BMI ≥24 kg/m^2 , NAFLD,and hypertension are the independent risk factors for hyperurieemia.