基于流固耦合模型的SUI患者尿液动力学研究

Urodynamics study of SUI patients based on the fluid-structure interaction model

目的针对当前压力型尿失禁(stress urinary incontinence,SUI)疾病严重影响中老年女性患者身体健康和生活质量的问题,开展女性盆底尿路系统尿液动力学的数值研究。方法依据尿液-盆底组织间相互作用的耦合特征,结合计算流体力学(computational fluid dynamics,CFD)技术,建立SUI疾病的尿液动力学模型,分析软组织结构的应变、应力和变形以及尿路系统中尿液流动的压力场、速度场分布。结果尿路系统弹性结构的应力、应变和位移随时间呈波浪形变化,是SUI疾病形成的力学要素。结论开展基于流固耦合模型的尿动力学研究不仅必要,而且可行,能为临床SUI疾病的手术治疗提供理论基础及技术分析手段。

Objective Aiming at solving the problem of the middle-aged and old women suffering from stress urinary incontinence （SUI）, which can seriously affect their physical and mental health, the numerical study on urodynamics in pelvic floor of the female urinary system is conducted. Methods According to the characteristics of interaction coupled between urine and pelvic organizations, the SUI urine dynamics model was established based on computational fluid dynamics. Thus, the stress, strain and displacement of the urine system, and the pres- sure or velocity distributions in the urine flow, were analyzed. Results The stress, strain and displacement of elastic structure in the urinary system fluctuated with time, which played the important role in the mechanical mechanism of SUI. Conclusions It is not only necessary but also available to apply the fluid-structure interaction model to study the urinary system of SUI, and the urodynamic simulations can provide the theoretical foundation and technological method for the prediction and assessment of SUI diseases in clinic.