LGG混悬液吊瓶灌肠疗法和兽药结合治疗幼犬大肠杆菌感染性腹泻

The treatment of LGG suspension clysis combined with veterinary medicine on infectious diarrhea of Escherichia coli in puppies

为观察鼠李糖乳杆菌(Lactobacillus rhamnosus,LGG)对大肠杆菌感染性腹泻疗效,采用不同剂量的鼠李糖乳杆菌对幼犬吊瓶灌肠和兽药治疗方法结合,以临床治疗处方药为对照,观察治疗5d后细菌感染性泻的止呕时间、止泻时间、粪便形成时间及治疗后粪便中大肠杆菌和双歧杆菌菌数变化和血常规变化。结果表明:治疗Ⅲ组(1×108 CFU/kg鼠李糖乳杆菌)比对照组明显缩短止吐和止泻时间,减少大便次数,且治疗第3天后大便完全成形,WBC、RBC、LY#和GR#均恢复正常。由第4和5天粪便标本中所含细菌菌属检测中发现,治疗Ⅲ组双歧杆菌菌数明显多于观察组幼犬粪便中双歧杆菌(P<0.05)菌属,且其治愈率97.97%(32/33)远远高于对照组治愈率87.88%(29/33)(P<0.05)。由此可见,治疗Ⅲ组(1×108 CFU/kg鼠李糖乳杆菌)的治疗效果最明显。

In order to observe the effect of rhamnosus LGG （Lactobacillus） on the treatment of infectious diarrhea of Escherichia coli, different doses of LGG combined with the treatment of veterinary medicine was used. Clinical prescription drugs as control, the antiemetic time, antidiarrheal time, stool formation time of bacterial diarrhea, and count changes of E. coli and bifidobacteria in feces, the changes of blood rountine after treatment of 5 days were observed. The results showed that the antiemetic and antidiarrheal time in the treatment group （1 × 108 CFU/kg of Lactobacillus rhamnosus） was significantly shorter than the control group, stool frequency reduced, stool was fully formed on 3d after treatment, WBC, RBC, LY# and GR# were normal. The number of bifidobacteria in feces of puppies of the treatment group III was significantly more than the control group on 4d and 5d （P〈0.05）, the cure rate was 97.97% （32/33） , it was higher than that of 87.88% （29/33） of control group （P〈0.05）. It showed that the effect of the treatment group III （1 × 108 CFU/kg Lactobacillus rhamnosu） was the most obvious.