氯己定全身擦浴预防ICU中心导管相关性血流感染的效果研究

Effect of whole-body bathing with chlorhexidine gluconate on prevention of central line-associated bloodstream infections in ICU

目的探讨氯己定全身擦浴预防ICU中心导管相关性血流感染发生的应用效果,为临床推广应用提供实践依据。方法采用历史性对照研究,选取医院ICU 2015年2月-2016年1月留置中心导管的241例患者作为研究对象,将2015年2-7月纳入的118例患者为对照组,采用温水全身擦浴,2015年8月-2016年1月纳入的123例患者为试验组,采用氯己定全身擦浴,比较两组中心导管相关性血流感染的发生率、发病率及发生时间。结果试验组中心导管相关性血流感染率及发病率显著低于对照组,且发生时间晚于对照组(P<0.05)。结论氯己定全身擦浴对预防ICU中心导管相关性血流感染的发生效果良好。

OBJECTIVE To explore the effect of whole-body bathing with chlorhexidine gluconate on prevention of central line-associated bloodstream infections in ICU so as to provide guidance for the clinical promotion and appli- cation. METHODS By means of historical control study, a total of 241 patients who were treated with central cath- eter indwelling were recruited as the study objects, 118 patients who were enrolled in the study from Feb to Jul, 2015 were assigned as the control group and were treated with whole-body bathing with warm water, while 123 patients who were enrolled in the study from Aug 2015 to Jan 2016 were set as the experimental group and were given the whole-body bathing with chlorhexidine gluconate. The incidence of central line-associated bloodstream in- fections, morbidity rate, and onsite time were compared between the two groups of patients. RESULTS The inci- dence of central line-associated hloodstream infections and morhidity rate were significantly lower in the experimen- tal group than in the control group, while the onsite time was later in the experimental group than in the control group （P〈0.05）. CONCLUSION The whole-body bathing with chlorhexidine gluconate can achieve significant effect on prevention of the central line-associated bloodstream infections in the ICU.