葛根素对老年女性骨质疏松髋关节术后下肢深静脉血栓形成的预防作用

Preventive effect of puerarin on the formation of deep venous thrombosis of lower extremity after hip surgery in elderly women with osteoporosis

目的:观察葛根素对老年女性骨质疏松髋关节术后下肢深静脉血栓(DVT)形成的预防作用。方法:选取河北省沧州市中心医院2012年1月至2014年1月收治的100例老年女性骨质疏松症股骨颈骨折拟行人工股骨头置换术患者,随机分为防治组(n=50)和对照组(n=50),对照组接受常规抗炎和抗凝治疗,防治组在对照组基础上加用葛根素注射液静脉滴注,每次400 mg,加入5%葡萄糖液500 m L,1次/d,15 d为1个疗程。治疗后比较两组患者DVT发生率,DVT早期诊断指标及血液流变学水平变化。结果:防治组的DVT发生率8.0%,明显低于对照组的24.0%,差异有统计学意义(P<0.05);且与对照组比较,血栓素A_2、血栓素A_2/前列环素比值、血浆同型半胱氨酸及血液流变学指标水平均明显降低,差异均有统计学意义(P<0.05)。结论:葛根素对老年女性骨质疏松髋关节术后下肢DVT形成具有预防保护作用。

Objective To observe the preventive effects of puerarinon development of deep vein thrombosis （DVT） in elderly women with osteoporosis after hip replacement. Methods 100 elderly women with osteoporosis who scheduled for femoral head arthrolastybetween January 2012 and January 2014 in Cangzhou Central Hospital were selected and then randomly divided into a study group （n = 50） and a control group （n = 50）. The control group received routine anti-inflammatory and anticoagulant therapy, while the study group received intravenous drip of puerarinof 400 mg mixed with 5% glucose liquid 500 ml daily for 15 days as a treatment course. After the treatment, DVT incidence rate, change of early diagnostic indexes and hemorheology were compared with their baselines. Results DVT incidence rate was significantly lowerin the study group than in the control group （8.0 % vs. 24.0%, P 〈 0.05）. Ascompare with the control group, thromboxane A2/prostacyclin, plasma homocysteine and hemorheologywere significantly reduced （P 〈 0.05）. Conclusions Puerarin has a preventive effect for deep vein thrombosis in elderly women with osteoporosis after hip replacement.