P75神经营养因子受体研究进展及骨折不愈合治疗新思路

Research progress of P75 neurotrophin receptor and new idea of nonunion treatment

目的综述P75神经营养因子受体(P75 neurotrophin receptor,P75NTR)研究进展,明确其作用机制,探讨其与骨折不愈合的关系,为骨折不愈合的治疗提供新思路。方法广泛查阅近年国内外与P75NTR相关的文献,分析总结其作用机制及骨折不愈合形成的病理因素。结果 P75NTR在骨折不愈合组织中表达,且能导致纤维蛋白降解缺陷、抑制血管生成,而后两者在骨折不愈合的发病中起重要作用。结论在骨折不愈合的治疗中,是否可通过阻断P75NTR的上述作用达到治疗目的,尚有待进一步研究证实。

Objective To review the research progress of P75 neurotrophin receptor （P75NTR） so as to clarify its mechanism, and to explore its relationship with nonunion so as to provide a new idea for the treatment of nonunion. Methods The related domestic and foreign literature of P75NTR in recent years was extensively reviewed, summarized, and analyzed to find out the mechanism of action of P75NTR and the pathological factors of nonunion formation. Results P75NTR can express in nonunion tissues and lead to defect of fibrin degradation and inhibition of angiogenesis, which play an important role in the pathogenesis of nonunion. Conclusion It needs to be confirmed by further study whether the purpose of treating nonunion can be achieved by blocking the effects described above of P75NTR.