肺损伤剂的毒理学机制及中毒救治

Toxicological mechanisms of lung injurant and poisoning management

肺是化学品中毒的重要靶器官。化学毒物通过肺的血液循环直接吸收进入人体,造成系统性损伤;或作为化学毒物的靶器官,直接使肺本身受到损伤。肺损伤往往较全身其他器官损伤更为迅速甚至危及生命。本文系统介绍了以肺为靶器官,以不同接触方式直接或间接地导致肺损伤的化学毒物,即肺损伤剂的毒理学机制与中毒救治策略。

The lung is one of the important target organs of chemical poisoning. Chemical toxins may be absorbed into body through blood circulation of the lungs,inducing systemic damage. Meanwhile,they may also directly damage the lungs themselves. Lung injury is usually rapid and life-threatening. This review systematically introduced the toxicological mechanisms and poisoning management of lung injury agents.