红细胞分布宽度与急性冠脉综合征相关性的研究

Correlation of red blood cell distribution width with acute coronary syndrome

目的：研究红细胞分布宽度（Red distribution width,RDW）与急性冠脉综合征（Acute coronary syndrome,ACS）患者住院期间发生不良心血管事件的关系,为ACS患者危险度分层提供新的参考指标。方法：选取2011年3月-2015年3月于我院心内科就诊的ACS患者130例,按RDW中位数分为高RDW组和低RDW组;同时选取稳定型心绞痛及冠脉造影正常患者100例作为对照组。比较组间住院期间主要不良心血管事件发生情况,包括：再发心肌梗死、心源性死亡、心力衰竭、恶性心律失常、顽固性心绞痛。结果：ACS组的RDW值较对照组明显增高（P〈0.05）;高RDW组ACS患者住院期间主要不良心血管事件的总发生率较明显高于低RDW组（P〈0.05）。多因素Logistic回归分析显示RDW可作为预测住院期间发生主要不良心血管事件的独立危险因素（OR：3.683,95%Cl：1.131-11.989,P〈0.05）。结论：RDW可作为ACS患者短期预后的独立预测因素。

Objective：To study the correlation of red blood cell distribution width（Red distribution width,RDW）and acute coronary syndrome patients with adverse cardiovascular events occurred during the period of hospitalization.Methods：Totally 130 patients with acute coronary syndrome were chose in our hospital during March 2011-March 2015.According to the median RDW,all patients were divided into high RDW and low RDW group.One hundred patients with stable angina pectoris and normal coronary angiography was chose as control group.The major adverse cardiac events,including：recurrence of myocardial infarction,cardiac death,heart failure,malignant arrhythmia,intractable angina pectoris were compared.Results：The RDW value in ACS group was significantly higher than control group（P〈0.05）.The total incidence of major adverse cardiac events in high RDW group of ACS patients was significantly higher than the low RDW group（P〈0.05）.The analysis of Multivariable Logistic regression showed that RDW can be predict independent risk factors for major adverse cardiovascular events（OR：3.683,95% ci：1.131 11.989,P〈0.05）.Conclusion：The RDW can be as an independent predictor of short-term prognosis in patients with ACS.