先天高胰岛素性低血糖症药学监护

Pharmaceutical care for a patient with congenital high insulin hypoglycemia

目的探讨先天高胰岛素性低血糖症患儿的药学监护。方法 1例先天高胰岛素性低血糖症患儿服用二氮嗪、氢氯噻嗪、氯化钾、奥曲肽后,临床药师通过监测其血糖水平、出入量和血电解质等情况,探讨低血糖发生的原因,药物对血糖的影响,以及临床药师对该类患儿的药学监护切入点。结果不同遗传学类型的先天高胰岛素性低血糖症患儿对药品的反应差异较大,药品对血糖的影响不尽相同,临床药师可以将此类患儿应选择的药品不良反应和注意事项作为药学监护的切入点。结论在先天高胰岛素性低血糖症患儿的治疗中,需根据患儿自身情况采用个体化治疗的策略,加强血糖检测,及时调整药品,以有效规避不良反应的发生。

Objective To explore the pharmaceutical care for a child with congenital high insulin hypoglycemia.Methods Clinical pharmacist monitored blood glucose levels,intake and output volume and blood electrolytes of a pediatric patient with congenital high insulin hypoglycemia who took diazoxide,hydrogen chloride,potassium chloride and octreotide,and then analyzed the causes of hypoglycemia and the effects of drugs on blood glucose and the time to provide the pharmaceutical care for the patient.Results The reaction of different genetic types of children with congenital high insulin hypoglycemia to drugs were different,and the influence of drugs on blood glucose was not the same.Clinical pharmacists chose the adverse drug reactions and attention as the entry points of pharmaceutical care.Conclusion Strategy of individualized treatment according to the situation of patients,strengthening the detection of blood glucose and adjusting drugs can effectively avoid the occurrence of adverse reactions in the treatment of children with congenital high insulin hypoglycemia.