磁共振T1ρ成像定量评估股骨头坏死患者软骨损伤

MR TIρ imaging in quantitative assessment of cartilage injury in patients with femur head necrosis

目的探讨磁共振T1ρ成像技术定量评估股骨头坏死患者软骨损伤的应用价值。方法对47例股骨头坏死初治患者及24名健康志愿者(对照组)行常规MR和T1ρ检査,通过工作站后处理计算定量参数T1ρ值。比较对照组及不同国际骨循环研究会(ARCO)分期患者的T1ρ值,并分析T1ρ值与ARCO分期的相关性。结果 47例股骨头坏死患者中,ARCOⅠ期6例,Ⅱ期13例,Ⅲ期28例。对照组、Ⅰ期、Ⅱ期、Ⅲ期患者的T1ρ值差异有统计学意义(F=5.73,P<0.01);Ⅲ期与对照组、Ⅰ期及Ⅱ期的T1ρ值差异有统计学意义(P均<0.05),其余两两比较差异均无统计学意义(P均>0.05)。T1ρ值与ARCO分期呈正相关(r_s=0.75,P<0.01)。结论 T1ρ成像技术可用于定量评估股骨头坏死患者的软骨损伤程度。

Objective To explore the value of MR T1ρ imaging in quantitative assessment of cartilage injury in patients with femur head necrosis.Methods Forty-seven newly diagnosed patients with femur head necrosis and twenty-four normal volunteers（control group） underwent conventional MRI and T1ρ examinations.Through the workstation post-processing,the quantitative parameters of T1ρ was calculated.The T1ρ were compared among control group and patients with different ARCO stages.The correlation between T1ρ value and ARCO stage was analyzed.Results In all 47 cases,there were 6 cases in stage Ⅰ,13 in stage Ⅱ,28 in stage Ⅲ.The differences of T1ρ among control group and patients groups with stage Ⅰ,Ⅱ,Ⅲ were statistically significant（F=5.73,P〈0.01）.The differences between stage Ⅲ and control group,stage Ⅰ,stage Ⅱ were significant（all P〈0.05）,and there were no significant differences between the other groups（all P〉0.05）.The value of T1ρ showed positive correlation with ARCO stage（rs = 0.75,P〈0.01）.Conclusion MR T1ρ imaging can be used for the quantitative assessment of cartilage injury in patients with femur head necrosis.