甘氨双唑钠对Ⅲ期非小细胞肺癌放疗增敏的临床观察

Sensitization-enhancing Efficacy of Glycididazole Natrium in the Radiotherapy of Patients with Stage Ⅲ of Non-small Cell Lung Cancer

目的观察甘氨双唑钠联合放疗治疗Ⅲ期非小细胞肺癌的近期疗效及安全性。方法 80例Ⅲ期非小细胞肺癌患者随机分为2组:增敏组和对照组,每组40例。增敏组患者使用甘氨双唑钠联合放疗,对照组仅行放疗。结果增敏组总有效率为95.0%,对照组为85.0%,差异有统计学意义(P<0.05)。2组患者在治疗中发生的毒副反应主要有放射性肺炎、放射性食管炎和骨髓抑制,2组发生率差异无统计学意义(P均>0.05)。结论甘氨双唑钠可明显提高Ⅲ期非小细胞肺癌的放疗敏感性,且在临床使用中安全可靠。

Objective To investigate the efficacy and safety of glycididazole natrium compared with radiotherapy in the treatment of patients with stage Ⅲ of non-small cell lung cancer. Methods Eighty patients with stage Ⅲ of non-small cell lung cancer were randomly divided into 2 groups,40 patients of the sensitization-enhancing group were treated with glycididazole natrium and radiotherapy,and 40 patients of the control group were only treated with radiotherapy. Results The total response rate of the sensitization-enhancing group was 95. 0%,and was 85. 0% of the control group（ P〈0. 05）. The main toxicities included radiation pneumonia,radiation esophagitis and bone marrow suppression,the difference of toxicities between the two groups were not significant（ P 0. 05）. Conclusion Administration of glycididazole natrium may enhance the radio-sensitivity of stage Ⅲ of non-small cell lung cancer without obvious toxicities.