前列腺小体与前列腺疾病的关系

Association between prostasomes and prostate disease

前列腺小体是由人类前列腺上皮细胞分泌的一种亚细胞结构，平均直径150nm（40～500nm）。前列腺小体含有440种蛋白质，具有多种功能。近期研究发现前列腺小体不仅可以延迟顶体反应，增加精子活力，还具有免疫调节功能、抗菌、抗氧化的功能。前列腺小体可以从血液和尿液中分离获得，在正常前列腺和前列腺癌组织中都存在，可以作为一个很好的前列腺特异性生物标记物。研究结果表明前列腺小体与前列腺炎、前列腺癌等疾病密切相关。

Prostasomes are one of the subcellular structures secreted by prostatic epithelial cells. They present in human semen as membranous vesicles with average diameter of 150nm （40- 500nm） .440 proteins have been identified in human prostasomes and possess many physical functions. Prostasomes may not only exert a motility function for spermatozoa by delaying the acrosome reaction, but also have immune regulatory function, antibacterial and antioxidant characteristics. Prostasomes can be isolated from the serum and urine,and they present both in normal and prostatic cancer tissues. Prostasome can be a special prostatic biomarker and has a close association with prostatitis and prostate cancer.