青年乳腺癌与中老年乳腺癌超声影像学对比研究

Comparative study of ultrasonographic features of breast carcinomas among young,middle-aged and elderly women

目的探讨青年乳腺癌与中年、老年乳腺癌在超声影像学、病理及免疫组化表现方面的差异。方法共收集乳腺癌患者162例,按年龄分为青年组（≤40岁）、中年组（41～59岁）和老年组（≥60岁）各54例。回顾分析三组乳腺癌在超声影像学、病理及免疫组化表现方面的差异。结果青年组超声恶性征象＂边缘毛刺征＂、＂周围高回声晕环＂、＂微小钙化灶＂、＂后发回声衰减＂、＂腋窝异常肿大淋巴结＂的比率均高于中年组和老年组（P〈0.05）。青年组浸润性非特殊性癌III级、肿瘤大小T3＋T4、腋下淋巴结转移的比率均高于中年组和老年组（P〈0.05）。青年组ER、PR阳性表达比率均低于中年组和老年组（P〈0.05）。结论青年乳腺癌与中老年乳腺癌相比具有恶性度高、侵袭性强及超声典型恶性征象发生率高的特点。

Objective To evaluate the differences of ultrasonographic,pathologic and immunohistochemical features of breast carcinomas among young,middle- aged and elderly women. Methods A total of 162 patients with breast cancer were enrolled. According to age,the 162 patients were divided into three groups,including youth- age group（ ≤40years old,54 cases）,middle- age group（ 41- 59 years old,54 cases）,and old- age group（ ≥60 years old,54 cases）. Retrospective analysis was performed to evaluate the differences of ultrasonographic,pathologic and immunohistochemical features among the three groups. Results The ratios of grade Ⅲ infiltrating non- specific carcinoma,tumor size T3 ＋ T4,axillary lymph node metastasis in the youth- age group were larger than those in the middle- age group and the old- age group（ all P〈0. 05）. The ER and PR positive rates in the youth- age group were lower than those in the middle- age group and the old- age group（ all P〈0. 05）; Compared with the middle- age group and the old- age group,the youth- age group more commonly presented with manginal apicule sign,hyperechoic halo,microcalcification,posterior shadowing and axillary lymph node enlargement on ultrasonographic imaging（ all P〈0. 05）. Conclusion Breast carcinomas of young women are more commonly presented with higher degree of malignancy,stronger invasiveness and typical malignant ultrasonographic features.