热性惊厥、GEFS＋、Dravet综合征与疫苗接种的关系

The relationship between vaccination and febrile seizure.GEFS ＋ and Dravet syndrome

对患有神经系统疾病儿童进行疫苗接种决策对于人们尤其是儿科医生来说是个棘手的问题，医生和家长们担心出现不良反应（如惊厥、疫苗脑病等）或考虑患儿存在热敏感性惊厥疾病的病史，担心疫苗接种导致惊厥发作，从而倾向于不给或不推荐其接种疫苗，而热性惊厥、GEFS＋、Dravet综合征这类热敏感性疾病是最常见的惊厥性疾病之一，其发病机制被证实多与SCN钠离子亚通道基因突变导致功能缺失相关。对于FS、GEFS、以及Dravet综合征的患儿，疫苗接种可能会导致发热，引起惊厥，但疫苗接种并不会使他们的预后变差。

Vaccination in children suffering neurological diseases is a troublesome issue that people es- pecially pediatricians are reluctant to mention. Due to worrying about the emergence of adverse reactions and concerning on the heat induced seizure, doctors and parents tend to cancel or do not recommend these children to be vaccinated. Additionally, the heat sensitive seizures, such as febrile seizure （FS）, generalized epilepsy with fe- brile seizure plus（ GEFS ＋ ）, Dravet syndrome account for the largest proportion of the seizure related disease and epilepsy syndrome. Their pathogenesis has been proved relating to the mutation of SCN gene of the sodium channel. For children with FS, GEFS ＋, and Dravet syndrome, vaccination may lead to fever, which even may bring about convulsions, but it will not result in worse prognosis.