盐酸纳洛酮治疗重型颅脑损伤的疗效分析

Analysis the Curative Effect of Naloxone in the Treatment of Serious Traumatic Brain Injury

目的分析盐酸纳洛酮在重型颅脑损伤(SBI)治疗中的临床疗效。方法选取2011年1月-2015年6月期间医院收治的60例SBI患者作为研究对象,根据不同治疗药物将患者分为观察组和对照组,两组各30例患者。对照组均接受常规临床治疗,观察组在对照组基础上应用盐酸纳洛酮催醒治疗。结果经治疗后,观察组总有效率96.7%,明显高于对照组(P<0.05);观察组患者意识恢复时间短于对照组(P<0.01);观察组残疾率、死亡率以及语言肢体功能障碍率均低于对照组(P<0.05);两组血浆CRP水平比较,差异有统计学意义(P<0.001);两组GCS评分比较差异有统计学意义(P<0.05)。结论临床常规治疗SBI的基础上应用盐酸纳洛酮能缩短患者意识恢复时间,降低残疾率、死亡率以及语言肢体功能障碍率,具有一定临床价值。

Objective To analyze the clinical efficacy of naloxone hydrochlofide in the treatment of severe traumatic brain injury （SBI） patients. Methods 60 cases with SBI during January 2011 to 2015 June in our hospital were selected as the research objects, according to the different therapeutic drugs divided into observation group and control group, two groups of 30 patients. The control group received routine clinical treatment, and the observation group was treated with naloxone hydrochloride on the basis of control group. Results After treatment, the total efficiency was 96.7% in the observation group, ad it is significance higher than control group （ P 〈 0.05 ） ; Patients in the observation group consciousness recovery time short than that of the control group （P 〈 0. 01 ） ; Observation group in the disability rate, mortality and patient body lan- guage dysfunction rate was lower than that of the control group （ P 〈 0. 05 ）. The plasma levels of CRP in two groups compared （ P 〈 0. 001 ） ; Two groups of GCS score （ P 〈 0. 05 ）, there are statistically significant. Conclusion Clinical application of naloxone hydrochloride on the basis of clinical routine treatment can shorten the recovery time of consciousness, reduce the rate of disability, mortality and the rate of limb dysfunction in patients, which has certain clinical value.