布拉酵母菌散剂联合小儿泻速停颗粒治疗轮状病毒肠炎的临床效果

Clinical effect of saccharomyces boulardii sachets combined with Xiesuting pellets in the treatment of infantile rotavirus enteritis

目的研究布拉酵母菌散剂联合小儿泻速停颗粒治疗轮状病毒肠炎的临床效果。方法将2015年1月至2016年1月本院收治的141例轮状病毒肠炎患儿根据门诊就诊病历号随机分为联合组、泻速停组及对照组。三组患儿均采用轮状病毒肠炎常规治疗方案,联合组患儿在此基础上加用布拉酵母菌散剂和小儿泻速停颗粒,泻速停组患儿加用小儿泻速停颗粒。治疗5天后评价三组的疗效。结果联合组和泻速停组总有效率(93.62%,91.49%)均高于对照组(76.60%)(P<0.05)。三组患儿退热时间、止泻时间及止吐时间比较依次为:联合组<泻速停组<对照组,且三组间两两比较差异显著(P<0.01)。治疗后三组患儿白介素(IL)-6、IL-8及肿瘤坏死因子-α(TNF-α)水平均明显低于治疗前(P<0.01),IL-6、IL-8及TNF-α水平比较依次为:联合组<泻速停组<对照组,且三组间两两比较差异显著(P<0.01)。结论布拉酵母菌联合小儿泻速停颗粒可有效缩短轮状病毒肠炎症状持续时间,减轻炎症损伤,尽快恢复患儿肠道屏障功能。

Objective To explore the clinical effect of saccharomyces boulardii sachets combined with Xiesuting pellets in the treatment of infantile rotavirus enteritis. Method 141 cases with infantile rotavirus enteritis were divided into combination group, Xiesuting group and control group randomly. All groups were treated with conventional rotavirus enteritis treatement. Combination group children added saccharomyces boulardii sachets and Xiesuting pellets into the treatment when Xiesuting group was added Xiesuting pellets. All children were treated for 5 days and evaluated the clinical effect. Result The total effective rate of combination group and Xiesuting group （93.62%, 91.49%） were higher than control group （76.60%） （P 〈 0.05）. Antifebrile time, antidiarrheal time and anti-nausea time among the three groups was combination group 〈 Xiesuting group 〈 control group （P 〈 0.01）. The levels ofIL-6, IL-8 and TNF-et after treatment were lower than before treatment （P 〈 0.01）; the levels of IL-6, IL-8 and TNF-ct after treatment among the three groups was combination group 〈 Xiesuting group 〈 control group （P 〈 0.01）. Conclusion The therapy which combines sacchaxomyces boulardii sachets and Xiesuting pellets can reduce the duration of symtoms and inflammatory injury caused by rotavirus. It＇s helpful of restorin~ the intestinal barrier function.