氨茶碱联合罗红霉素治疗支气管扩张的效果

Aminophylline combined with roxithromycin in treatment of bronchiectasis

目的研究氨茶碱联合罗红霉素治疗支气管扩张的效果及对肺功能的影响。方法将本院2013年8月至2015年12月收治的84例支气管扩张患者随机分为对照组与实验组，各42例。对照组采用罗红霉素治疗，实验组采用氨茶碱与罗红霉素联合治疗。比较两组治疗效果、治疗前后肺功能指标变化。结果治疗后，两组PEF、FEV，及FVC指标均有所提高，但对照组肺功能指标提高程度低于实验组，差异有统计学意义（P〈0．05）；对照组治疗有效率（76．2％）低于实验组（92．9％），差异有统计学意义（P〈0．05）。结论氨茶碱联合罗红霉素治疗支气管扩张效果显著，可改善患者肺功能，提高患者生活质量。

Objective To study the effect of aminophylline combined with roxithromycin in the treatment of bronchiectasis and its effects on pulmonary function. Methods 84 patients with bronchiectasis treated at our hospital from August, 2013 to December, 2015 were randomly divided into a control group and an experimental group, 42 cases for each group. The control group were treated with roxithromycin and the experimental group aminophylline and roxithromycin. The therapeutic effects and the changes of pulmonary function indexes were compared between these two groups before and after treatment. Results After treatment, the PEF, FEVI, and FVC were improved in both groups, but less in the control group than in the experimental group, with statistical differences （P 〈 0.05）. The treatment efficacy was lower in the control group than in the experimental group （76.2% vs. 92.9%）, with a statistical difference （P 〈 0.05）. Conclusions Aminophylline combined with roxithromycin in the treatment of bronchiectasis is significantly effective and can improve lung function and the quality of life.