自噬在病毒性心肌炎中的研究进展

Advances in autophagy research of viral myocarditis

研究发现自噬参与了病毒性心肌炎的发生发展过程。自噬在抗病毒感染中起重要作用，宿主细胞可利用自噬降解病毒、递呈病毒抗原、激发免疫反应等机制来发挥保护作用。然而病毒也利用自噬，维持自身的存活和复制，最终成为感染的加速器。在病毒性心肌炎中，病毒与宿主细胞自噬的相互作用是一个复杂的过程，其详细的作用机制尚待进一步研究发现。

Recent studies have found that autophagy was not only involved both in the occurrence and development of viral myocarditis （VMC）, but also, it plays a key role in anti -viral infections by degradating the viral components, presenting viral antigens and activating the immune response. Meanwhile, the virus can also escape the protective antiviral activity and maintain their own survival and replication by inducing the autophagy of the host ceils, becoming the accelerator of the viral infection. The interaction of the virus and the host cell autophagy in VMC is a complex process. Its detailed pathogenesis has yet to be further explored.