火龙果皮化学成分的研究

Chemical constituents from Hylocereus undatus peels

目的研究火龙果Hylocereus undatus cv.Vietnam皮的化学成分。方法应用硅胶、ODS、半制备HPLC柱,对火龙果皮95%乙醇提取物的乙酸乙酯和正丁醇部位进行分离纯化,通过波谱数据对所得化合物的结构进行鉴定。结果从中分离出13个化合物,分别鉴定为香蒲新苷(1)、山柰酚-3-O-β-D-葡萄吡喃糖基-(1→2)-[α-L-鼠李吡喃糖基-(1→6)-β-D-葡萄吡喃糖苷](2)、槲皮素-3-O-新橙皮糖苷(3)、异鼠李素-3-O-芸香糖苷(4)、3'-甲氧基槲皮素-3-O-α-L-鼠李吡喃糖基-(1→6)-β-D-葡萄吡喃糖苷(5)、苄醇-β-D-葡萄糖苷(6)、大黄素-6-甲醚(7)、白藜芦醇(8)、腺嘌呤核苷(9)、尿嘧啶核苷(10)、2-甲氧基-3-(3'-吲哚基)-丙酸(11)、α-菠菜甾醇(12)、β-谷甾醇(13)。结论化合物1~12均为首次从该植物中分离得到。

AIM To study the chemical constituents from Hylocereus undatus cv. Vietnam peels. METHODS The ethyl acetate and n-butyl alcohol fractions of 95% ethanol extract of H. undatus peels were isolated and purified by silica,ODS and semi-preparative HPLC column,then the structures of obtained compounds were identified by spectral data. RESULTS Thirteen compounds were isolated and identified as typhaneoside（ 1）,kaempferol-3-O-β-D-glucopyranosyl-（ 1 → 2）-[α-L-rhamnopyranosyl-（ 1 → 6）-β-D-glucopyranoside ]（ 2）,quercetin-3-O-neohesperidoside（ 3）,isorhamnetin-3-O-α-L-rhamnopyranosyl（ 1→2）-β-D-glycopyranoside（ 4）,3＇-O-methylquercetin-3-O-α-L-rhamnopyranosyl-（ 1 →6）-β-D-glucopyranoside（ 5）,benzyl alcohol-β-D-glucopyranoside（ 6）,physcion（ 7）,resveratrol（ 8）,adenosine（ 9）,uridine（ 10）,2-methyl-3-（ 3＇-indolyl）-propionic acid（ 11）,α-spinasterol（ 12）,β-sitosterol（ 13）. CONCLUSION Compounds 1-12 are isolated from this plant for the first time.